Low systolic blood pressure (<90 mm Hg) was associated with increased mortality from atherosclerotic vascular disease compared to SBP of 90-99 mm Hg (HR 1.53; 95% CI 1.15-2.03).
Cohort (n=1,235,246)
Does low systolic blood pressure (<90 mm Hg) increase the risk of mortality from atherosclerotic vascular diseases in adults?
There is a J-curve association between systolic blood pressure and vascular mortality, with SBP <90 mm Hg associated with an increased risk of death from atherosclerotic vascular disease, particularly ischemic heart disease.
Hazard Ratio: 1.53 (95% CI 1.15–2.03)
BACKGROUND: The association between low systolic blood pressure (SBP) and vascular disease is unclear, especially in nonclinical populations. METHODS AND RESULTS: We studied 1 235 246 individuals who participated in routine medical examinations between 1992 and 1995. The hazard ratios (HRs) were adjusted for potential confounders. During 22.7 million person-years of follow-up, 34 816 individuals died of atherosclerotic vascular diseases. An increase in SBP was directly related to an increase in vascular mortality at SBP above ≈100 mmHg. The group with the lowest SBP (<90 mm Hg) had a higher HR for mortality from atherosclerotic vascular disease (HR, 1.53; 95% confidence interval, 1.15-2.03) in comparison with those with an SBP of 90 to 99 mm Hg. The HR associated with the lowest SBP was 2.54 (95% confidence interval, 1.51-4.29) for ischemic heart disease and 1.21 (95% confidence interval, 0.79-1.85) for stroke. Regarding stroke subtype, mortality from hemorrhagic stroke (HR per 10 mm Hg increase, 0.53; 95% confidence interval, 0.29-0.96), rather than mortality from ischemic stroke (HR per 10 mm Hg increase, 1.00; 95% confidence interval, 0.51-1.97), was inversely associated with SBP when SBP fell to <100 mm Hg. Even when excluding the first 5 years of follow-up, the HRs associated with the lowest SBP did not decrease. The inverse association between SBP and vascular mortality in the range <100 mm Hg tended to be apparent in people aged 60 to 95 years in comparison with individuals aged 30 to 59 years. CONCLUSIONS: J-curve associations exist between SBP and vascular mortality, which reach a nadir at ≈100 mm Hg. SBP of <90 mm Hg may portend death from vascular disease, particularly from ischemic heart disease.
Yi et al. (Thu,) conducted a cohort in General population (n=1,235,246). Low systolic blood pressure (<90 mm Hg) vs. SBP of 90 to 99 mm Hg was evaluated on Mortality from atherosclerotic vascular disease (HR 1.53, 95% CI 1.15-2.03). Low systolic blood pressure (<90 mm Hg) was associated with increased mortality from atherosclerotic vascular disease compared to SBP of 90-99 mm Hg (HR 1.53; 95% CI 1.15-2.03).