Case Report (n=1)
No
Takotsubo cardiomyopathy can acutely worsen left ventricular outflow tract obstruction in patients with preexisting hypertrophic cardiomyopathy, which can be successfully managed with beta-blockers and supportive care.
Highlights potential LVOTO risk in HCM with Takotsubo; hypothesis-generating, requiring prospective confirmation before practice implications.
Takotsubo cardiomyopathy (TCM) is a condition characterized by transient left ventricular dysfunction and apical ballooning, best seen on an echocardiogram or left ventriculogram. It mimics acute myocardial infarction but without evidence of coronary artery disease on an angiogram. Hypertrophic cardiomyopathy (HCM) is an autosomal dominant heart muscle disease that is significant with hypertrophy of the left ventricle with various morphologies. We hereby report a case of TCM in a male patient with a known history of HCM. The patient's hemodynamic findings were challenging because the TCM produced an increased left ventricular outflow tract (LVOT) gradient that was previously not seen on his prior echocardiogram or cardiac catheterizations. Assessment and continuous monitoring are warranted in such a rare case. Supportive care afterward with beta blockers, along with echocardiogram surveillance, are the mainstay of management of such a patient.
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Elhosseiny et al. (2018) conducted a case report in Takotsubo Cardiomyopathy and Hypertrophic Cardiomyopathy (n=1). Metoprolol succinate was evaluated on Resolution of Takotsubo cardiomyopathy and LVOT gradient.
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