Why the study?
Does consecutive divided daily doses of doxorubicin reduce cardiotoxicity in children with malignancy compared to a single dose infusion?
Does consecutive divided daily doses of doxorubicin reduce cardiotoxicity in children with malignancy compared to a single dose infusion?
A divided daily dose schedule of doxorubicin does not reduce the incidence of cardiotoxicity in children compared to a single dose infusion, though girls may be at higher risk than boys.
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Divided dosing should not yet change pediatric practice; leaves open sex-specific risks and need for randomized confirmation.
Ewer et al. (1998) studied this question.
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