Key result
A single bout of high-intensity exercise to exhaustion significantly increased mean plasma endostatin concentration by 34% at 30 minutes post-exercise.
Why the study?
The study investigated the circulatory concentration of endostatin and the impact of exercise intensities ranging from low to maximum on plasma endostatin and VEGF concentrations.
Does maximal intensity exercise to exhaustion alter plasma concentrations of endostatin and VEGF in healthy male volunteers?
Does maximal intensity exercise to exhaustion alter plasma concentrations of endostatin and VEGF in healthy male volunteers?
Short periods of high-intensity exercise to exhaustion transiently increase plasma concentrations of the angiogenic markers endostatin and VEGF in healthy males.
Answers are grounded in this paper and cite their sources.
Transient endostatin rise after exhaustive exercise should not change practice; leaves open its role in vascular adaptations pending larger trials.
Endostatin and Vascular Endothelial Growth Factor (VEGF) are important markers driving the angiogenic switch. It is clear that short periods of moderate to high intensity exercise significantly increase the concentration of endostatin and VEGF in plasma. Objective: To investigate concentration of circulatory endostatin in plasma and impact of different intensities of exercise encompassing from low to maximum on distribution of endostatin and VEGF concentrations in plasma. Methods: Eight healthy male volunteers were recruited through advertisements and personal contacts, after assessing their fitness through two pre-participation health screening questionnaires, PAR-Q and ACSM Health Fitness Facility pre-participation health screening questionnaire for performing maximal exercise to volitional exhaustion. All the volunteers attend the lab on 2 consecutive days. The blood was centrifuged at 1000 RPM for 15 minutes for endostatin and VEGF and at 3000 RPM for 15 minutes for lipid profiles and insulin. Samples were analysed for endostatin and VEGF concentrations using QuantikinR ELISA kit of the R&D systems, while Insulin was measured using ELISA kit (Mercodia, Uppsala Sweden). Results: The basal endostatin concentration remained consistent and higher intensity of exercise significantly increased the endostatin concentration for up to 2 hours. Exercise also influenced VEGF concentration transiently and only at 30 minutes’ interval increase in VEGF was statistically significant. Conclusion: It is worth noting that those participants who showed an immediate decrease in VEGF after exercise, later on exhibited a concentration higher than basal
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Shah et al. (2022) studied Healthy (n=8). High intensity exercise to exhaustion vs. Baseline was evaluated on Plasma endostatin concentration at 30 minutes post-exercise (34% increase, p=<0.001). A single bout of high-intensity exercise to exhaustion significantly increased mean plasma endostatin concentration by 34% at 30 minutes post-exercise.
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