Population
Caenorhabditis elegans (smg(+) and smg(-) genetic backgrounds)
Comparison
smg gene mutations vs smg(+) genetic background
Design
Preclinical
Authors
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NMD pathway identification in C. elegans; leaves open validation in mammalian cardiovascular models.
The smg genes in C. elegans eliminate mRNAs containing premature stop codons, protecting cells from potentially toxic protein fragments.
Pulak et al. (1993) studied this question.
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