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August 22, 2008Colorectal Disease

Can elderly patients with colorectal cancer tolerate planned surgical treatment? A practical approach to a common dilemma

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Key result

P-POSSUM and CR-POSSUM accurately predicted 30-day mortality in elderly colorectal cancer patients (expected 11.21% and 13.08% vs observed 10.3%, P=NS), but P-POSSUM overestimated morbidity.

Why the study?

Do P-POSSUM and CR-POSSUM accurately predict 30-day mortality and morbidity in elderly patients undergoing colorectal cancer surgery?

Population

177 consecutive patients over 70 years of age undergoing emergency or elective colorectal cancer surgery

Design

Cohort

Follow-up

30-day

Authors

GUGiampaolo UgoliniOspedale "Santa Maria delle Croci" di RavennaGRG. RosatiHospital General Universitario de ElcheIMIsacco MontroniTumour Institute of Tuscany

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Overview

May support mortality risk assessment in elderly colorectal cancer surgery; leaves open morbidity model refinement and prospective validation.

Study Design

Type

Cohort (n=177)

Structured PICO

Do P-POSSUM and CR-POSSUM accurately predict 30-day mortality and morbidity in elderly patients undergoing colorectal cancer surgery?

P
Population
177 consecutive patients over 70 years of age undergoing emergency or elective colorectal cancer surgery, assessed for 30-day mortality and morbidity.
E
Exposure
P-POSSUM and CR-POSSUM scoring systems
O
Outcome
30-day mortality and overall morbidityhard clinical

Main Result

Absolute Event Rate: 11.21% vs 10.3%

p-value: p=NS

P-POSSUM and CR-POSSUM accurately predict 30-day mortality in elderly colorectal cancer patients, but P-POSSUM significantly overestimates morbidity.

Cite This Study

Ugolini et al. (2008) conducted a cohort in Colorectal cancer (n=177). P-POSSUM and CR-POSSUM scoring systems vs. Observed outcomes was evaluated on 30-day mortality (p=NS). P-POSSUM and CR-POSSUM accurately predicted 30-day mortality in elderly colorectal cancer patients (expected 11.21% and 13.08% vs observed 10.3%, P=NS), but P-POSSUM overestimated morbidity.

synapsesocial.com/papers/6a20e85be72f0fa382ecbb2fhttps://doi.org/10.1111/j.1463-1318.2008.01676.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Audit of definitive colorectal surgery in patients with early and advanced colorectal cancer2002 · 17 citations
  2. 2Risk factors for morbidity and mortality after colectomy for colon cancer2000 · 424 citations
  3. 3Systematic review of the quality of surgical mortality monitoring2003 · 72 citations
  4. 4POSSUM, p-POSSUM, and Cr-POSSUM: Implementation Issues in a United States Health Care System for Prediction of Outcome for Colon Cancer Resection2004 · 109 citations
  5. 5Operative mortality rates among surgeons2000 · 113 citations