Why the study?
Does TPA induce alterations in vinculin and actin distribution in cultured human renal epithelium?
Population
Cultured human renal epithelium
Design
Preclinical
Authors
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TPA effects on renal epithelial cytoskeleton warrant no clinical translation; leaves open utility as a tumor progression model.
Does TPA induce alterations in vinculin and actin distribution in cultured human renal epithelium?
TPA induces reversible morphological and cytoskeletal changes in human renal epithelium that mimic epigenetic changes during tumour progression.
Rahilly et al. (1992) studied this question.
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