Key result
Increased intracellular calcium significantly activated the adult fast myosin heavy chain IIa promoter via calcineurin, calcium-calmodulin kinase, MEK1/MEK2, MEKK1, MEF-2, and NFAT pathways.
Intracellular calcium signaling mediates fast-to-slow skeletal muscle fiber type transitions by activating the MyHC IIa promoter via specific kinase and transcription factor pathways.
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Mechanistic insight into calcium-driven myosin IIa activation; hypothesis-generating for muscle adaptation in human disease and requires validation.
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Allen et al. (2002) studied Muscle biology. Increased intracellular calcium was evaluated on Activity of adult fast myosin heavy chain (MyHC) promoters. Increased intracellular calcium significantly activated the adult fast myosin heavy chain IIa promoter via calcineurin, calcium-calmodulin kinase, MEK1/MEK2, MEKK1, MEF-2, and NFAT pathways.
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