Why the study?
Does brief exposure to endotoxin impair endothelial function in healthy volunteers?
Does brief exposure to endotoxin impair endothelial function in healthy volunteers?
Brief local exposure to endotoxin causes prolonged but reversible endothelial dysfunction ('endothelial stunning'), providing a potential mechanistic link between infection/inflammation and acute cardiovascular events.
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Supports mechanistic link between endotoxin and reversible endothelial dysfunction; hypothesis-generating for infection-triggered events in humans.
Bhagat et al. (1996) studied this question.
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