Key result
Local infusion of arachidonic acid produced dose-dependent venodilatation that was abolished by a high dose of aspirin (1 g) but not a low dose (75 mg).
Why the study?
Does local infusion of arachidonic acid alter vascular tone in healthy volunteers, and is this effect modulated by different doses of aspirin?
Does local infusion of arachidonic acid alter vascular tone in healthy volunteers, and is this effect modulated by different doses of aspirin?
Local generation of prostanoids in human vessels in vivo alters vascular tone, and this synthesis is blocked by anti-inflammatory (1 g) but not cardioprotective (75 mg) doses of aspirin.
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Venous prostanoid effects shown in healthy volunteers; leaves open relevance to arterial tone or disease states.
Bhagat et al. (1995) studied Healthy volunteers. Arachidonic acid infusion and aspirin was evaluated on Venodilatation of preconstricted superficial hand veins. Local infusion of arachidonic acid produced dose-dependent venodilatation that was abolished by a high dose of aspirin (1 g) but not a low dose (75 mg).
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