What is the clinical evidence from this study?

Population: Canine hindlimb vascular responses (animal model) (n=4). Intervention: Indomethacin vs. Control (before indomethacin). Primary outcome: Hindlimb perfusion pressure (vascular response to dilator agonists) (p=<0.05).

September 1, 1980Journal of Pharmacy and Pharmacology

Responses to arachidonic acid and other dilator agonists and their modification by inhibition of prostaglandin synthesis in the canine hindlimb

Q: What are the key findings of this study?

Indomethacin significantly increased the vascular responsiveness of the canine hindlimb to dilator substances except arachidonic acid (P<0.05).

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Key result

Indomethacin significantly increased the vascular responsiveness of the canine hindlimb to dilator substances except arachidonic acid (P<0.05).

Why the study?

Does indomethacin modify the vasodilatory response to various agonists in the canine hindlimb?

Structured PICO

Does indomethacin modify the vasodilatory response to various agonists in the canine hindlimb?

Population

Canine hindlimb preparations (n=4) used to examine vascular responses to dilator agonists before and after indomethacin administration.

Intervention

Indomethacin 5 mg kg-1 i.v.

Comparator

Control (baseline responses before indomethacin administration)

Outcome

Change in hindlimb perfusion pressure (absolute mmHg and percent change) in response to intra-arterial dilator agonistssurrogate

Main Result

p-value: p=<0.05

Indomethacin non-specifically increases vascular responsiveness to dilator agonists in the canine hindlimb, indicating that their vasodilatory effects are not mediated by endogenous prostaglandins.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not support NSAID changes in patients; hypothesis-generating for prostaglandin-independent vasodilation in humans.

Cite This Study

Esteban Morcillo (1980) studied Canine hindlimb vascular responses (animal model) (n=4). Indomethacin vs. Control (before indomethacin) was evaluated on Hindlimb perfusion pressure (vascular response to dilator agonists) (p=<0.05). Indomethacin significantly increased the vascular responsiveness of the canine hindlimb to dilator substances except arachidonic acid (P<0.05).

synapsesocial.com/papers/6a97cdf448723bb28e366c9e https://doi.org/10.1111/j.2042-7158.1980.tb12932.x

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Responses to arachidonic acid and other dilator agonists and their modification by inhibition of prostaglandin synthesis in the canine hindlimb

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Responses to arachidonic acid and other dilator agonists and their modification by inhibition of prostaglandin synthesis in the canine hindlimb

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider