Why the study?
Do prostaglandin synthesis inhibitors alter renal vascular resistance and responses to vasoactive agents in the feline kidney?
Population
In situ feline kidney (cats)
Comparison
Indomethacin and meclofenamate vs Baseline conditions and responses with/without…
Design
Preclinical
Authors
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Prostaglandin synthesis inhibitors may raise feline renal vascular resistance via angiotensin II; leaves open translation to human cardiorenal physiology.
Do prostaglandin synthesis inhibitors alter renal vascular resistance and responses to vasoactive agents in the feline kidney?
In the feline kidney, the increase in renal vascular resistance caused by prostaglandin synthesis inhibitors appears dependent on the renin-angiotensin system rather than the adrenergic system.
Chapnick et al. (1977) studied this question.
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