Why the study?
Do prostaglandin synthesis inhibitors (indomethacin or meclofenamate) alter renal blood flow and vascular resistance under basal and ischemic conditions in dogs?
Population
Pentobarbital-anesthetized dogs
Comparison
Intra-arterial infusion of indomethacin or… vs Basal conditions vs. renal ischemia
Design
Preclinical
Authors
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Prostaglandin synthesis inhibitors may increase renal vascular resistance during ischemia in dogs; leaves open relevance to human renal hemodynamics.
Do prostaglandin synthesis inhibitors (indomethacin or meclofenamate) alter renal blood flow and vascular resistance under basal and ischemic conditions in dogs?
Prostaglandin synthesis inhibitors markedly increase renal vascular resistance during renal ischemia but not under basal conditions, suggesting prostaglandins play a key role in maintaining renal blood flow during ischemia.
Satoh et al. (1975) studied this question.
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