Why the study?
Do prostaglandin synthetase inhibitors affect the autoregulation of renal blood flow in rats?
Population
Nondiuretic rats anesthetized with either sodium pentobarbital or Inactin
Comparison
Prostaglandin synthetase inhibitors vs Baseline state without prostaglandin synthetase…
Design
Preclinical
Authors
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Renal autoregulation appears prostaglandin-independent in rats; leaves open translation to human renal hemodynamics or synthetase inhibitor effects.
Do prostaglandin synthetase inhibitors affect the autoregulation of renal blood flow in rats?
In rats, autoregulation of renal blood flow occurs independently of prostaglandin activity, but prostaglandins modulate the renal vascular actions of angiotensin II.
Finn et al. (1976) studied this question.
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