Key result
Indomethacin reduces renal blood flow ~20% without improving impaired autoregulation in remnant kidneys.
Why the study?
The role of vasodilatory prostaglandins in renal vasodilation, impaired autoregulation, and increased renin secretion in the rat remnant kidney model was unclear.
Comparison
Indomethacin administration vs no indomethacin (standard protein or low-protein diet)
Design
Preclinical experimental study
Authors
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Indomethacin reduces RBF in remnant kidney rats; leaves open prostaglandin mediation of impaired autoregulation in human CKD.
Absolute Event Rate: 5.9% vs 7.4%
p-value: p=<0.05
Prostaglandins contribute to renal vasodilation in the rat remnant kidney model but do not mediate impaired renal autoregulation or increased renin release.
Griffin et al. (1992) studied Rat remnant kidney model (n=34). Indomethacin vs. Pre-administration baseline was evaluated on Renal blood flow (ml/min) (p=<0.05). In a rat remnant kidney model, indomethacin administration decreased renal blood flow from 7.4 to 5.9 ml/min (P<0.05) but did not improve impaired autoregulation or alter renin secretion.
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