July 1, 1988Hypertension

Suppression of angiotensin II release by prostaglandin synthesis inhibitors in hind legs.

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Population

Isolated perfused rat hind leg vasculature

Design

Preclinical

Authors

KMK MizunoImperial Household Agency KHKoichi HigashimoriThe University of Osaka TITadashi InagamiHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

No immediate clinical implications for hypertension; leaves open prostaglandin modulation of vascular renin-angiotensin system in humans.

Structured PICO

Population

Isolated perfused rat hind leg vasculature

Intervention

Indomethacin and meclofenamate (10(-8) to 2 X 10(-6) M), isoproterenol (10(-6) M), and propranolol (10(-6) M) added to perfusion medium

Outcome

Release of immunoreactive Angiotensin I (Ang I) and Angiotensin II (Ang II) into the perfusatesurrogate

Prostaglandin synthesis inhibitors suppress the release of angiotensin I and II in isolated rat hind leg vasculature, suggesting modulation of the vascular renin-angiotensin system by prostaglandins.

Cite This Study

Mizuno et al. (1988) studied this question.

synapsesocial.com/papers/6a8c2edc0ca85c7e33df2fca https://doi.org/10.1161/01.hyp.12.1.67

View Full Paper

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Suppression of angiotensin II release by prostaglandin synthesis inhibitors in hind legs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Suppression of angiotensin II release by prostaglandin synthesis inhibitors in hind legs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider