December 1, 1979Journal of Clinical InvestigationOpen Access

Attenuation of Angiotensin II- and III-induced Aldosterone Release by Prostaglandin Synthesis Inhibitors

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Population

Normal and sodium-depleted conscious rats and adrenal capsular cell suspensions obtained from normal rats

Comparison

Prostaglandin synthesis inhibitors administered… vs Control conditions without prostaglandin…

Design

Preclinical

Authors

WCWilliam B. CampbellGeneral / Preventive / Lipids CGCelso E. Gómez-SánchezUniversity of Mississippi Medical Center BABeverley V. AdamsUniversity of Texas Health Science Center at Dallas

Discussion

Member takes

Implication

Animal data link prostaglandins to angiotensin-stimulated aldosterone; human studies required before clinical relevance.

Structured PICO

Population

Normal and sodium-depleted conscious rats and adrenal capsular cell suspensions obtained from normal rats

Intervention

Prostaglandin synthesis inhibitors (indomethacin 3 mg/kg or 10 mg/kg, or meclofenamate 2 mg/kg) administered with Angiotensin II or Angiotensin III

Comparator

Control conditions without prostaglandin synthesis inhibitors

Outcome

Serum aldosterone concentrations and aldosterone release in cell suspensionssurrogate

Prostaglandin synthesis inhibitors attenuate angiotensin-induced aldosterone release, suggesting prostaglandins modulate the renin-angiotensin system's steroidogenic effects.

Cite This Study

Campbell et al. (1979) studied this question.

synapsesocial.com/papers/6a86d18f36c36f97809eb840 https://doi.org/10.1172/jci109615

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Attenuation of Angiotensin II- and III-induced Aldosterone Release by Prostaglandin Synthesis Inhibitors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Attenuation of Angiotensin II- and III-induced Aldosterone Release by Prostaglandin Synthesis Inhibitors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider