Why the study?
Does beta-adrenoceptor stimulation increase the release of vascular angiotensin II in isolated rat mesenteric arteries?
Population
Isolated rat mesenteric arteries from spontaneously hypertensive rats and Wistar-Kyoto rats
Comparison
Isoproterenol infusion, with or without… vs Baseline or unblocked isoproterenol infusion
Design
Preclinical
Authors
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Beta-2 stimulation may modulate vascular tone via local ANG II in rats; leaves open human relevance and requires prospective confirmation.
Does beta-adrenoceptor stimulation increase the release of vascular angiotensin II in isolated rat mesenteric arteries?
Beta-2 adrenoceptor activation stimulates the local release of angiotensin II in rat mesenteric arteries, highlighting a potential mechanism for regulating peripheral vascular tone.
Nakamaru et al. (1986) studied this question.
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