Why the study?
Does a single dose of 325 mg aspirin increase sympathetic-mediated venoconstriction in healthy volunteers?
Population
12 healthy volunteers, mean age 24.5 +/- 0.8 years (range 19 to 30 years)
Comparison
Single dose of 325 mg aspirin vs Matching placebo
Design
RCT, randomized, matching placebo
Follow-up
not less than 90 minutes after dose
Authors
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Aspirin augments sympathetic venoconstriction in healthy volunteers; extends understanding of its acute vascular effects and warrants study in disease states.
Does a single dose of 325 mg aspirin increase sympathetic-mediated venoconstriction in healthy volunteers?
A single 325 mg dose of aspirin increases sympathetic-mediated venoconstriction and vascular resistance during physiologic stress in healthy young subjects.
Dzeka et al. (2000) studied this question.
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