Key result
Low-dose aspirin (100 mg) was associated with greater acetylcholine-induced coronary vasodilation compared to high-dose aspirin (P=0.0231) or no aspirin (P=0.0043) in subjects with normal coronaries.
Why the study?
Does aspirin improve coronary endothelial function in subjects with angiographically normal coronary arteries?
Observational (n=139)
Does aspirin improve coronary endothelial function in subjects with angiographically normal coronary arteries?
p-value: p=0.0043
Low-dose aspirin (100 mg), but not high-dose (500 mg), improves coronary endothelial function in patients with normal coronary arteries.
Hypothesis-generating for low-dose aspirin endothelial effects; should not yet change practice pending randomized data.
AIM: To investigate the effects of different doses of aspirin on coronary endothelial function. METHODS: The study included 139 Japanese subjects (mean age, 60 years; 53 women) with angiographically normal coronary arteries. Patients were distributed into Group I (n = 63), who was administered aspirin and Group II (n = 76), the control, who were not administered aspirin. Group I was further divided into Group Ia (n = 50, low-dose aspirin, 100 mg) and Group Ib (n = 13, high-dose aspirin, 500 mg). After a routine coronary angiography, acetylcholine (ACh; 3 and 30 μg/min successively) and nitroglycerin (NTG) were infused into the left coronary ostium over 2 min. The change in the diameter of the coronary artery in response to each drug was expressed as the percentage change from baseline values. RESULTS: The patient characteristics did not differ between the two groups. The change in coronary diameter in response to ACh was greater in Group I than in Group II (P = 0.0043), although the NTG-induced coronary vasodilation was similar between groups. ACh-induced dilation was greater in Group Ia than in Group Ib (P = 0.0231). Multivariate regression analysis showed that a low-dose of aspirin (P = 0.0004) was one of the factors associated with ACh-induced dilation at 30 μg/min. CONCLUSION: In subjects with angiographically normal coronary arteries, aspirin only had a positive influence on coronary endothelial function at the low dose of 100 mg. This improvement of coronary endothelial function may be involved in the preventive effect of aspirin against future coronary events.
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Hiroki Teragawa (2013) conducted an observational in Angiographically normal coronary arteries (n=139). Aspirin vs. No aspirin was evaluated on Change in coronary artery diameter in response to acetylcholine (p=0.0043). Low-dose aspirin (100 mg) was associated with greater acetylcholine-induced coronary vasodilation compared to high-dose aspirin (P=0.0231) or no aspirin (P=0.0043) in subjects with normal coronaries.
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