Key result
Aspirin /day increased the augmentation index of reflected wave and decreased reflected wave traveling times compared to placebo in CHF patients on ACEIs.
Why the study?
Does aspirin alter arterial functional properties in patients with chronic heart failure treated with ACE inhibitors?
Does aspirin alter arterial functional properties in patients with chronic heart failure treated with ACE inhibitors?
High-dose aspirin (325 mg/day) has a dose-mediated deleterious effect on arterial functional properties in chronic heart failure patients treated with ACE inhibitors.
Answers are grounded in this paper and cite their sources.
High-dose aspirin may impair arterial function in ACEI-treated CHF; leaves open effects on outcomes and need for prospective trials.
BACKGROUND: By inhibiting prostaglandin synthesis, aspirin can interfere with both arterial functional and angiotensin-converting enzyme inhibitor (ACEI) properties and be deleterious in chronic heart failure (CHF). AIM: Our aim was to prospectively evaluate the effect of aspirin on arterial functional properties in CHF patients treated with ACEIs. METHODS AND RESULTS: Over three consecutive treatment periods of 7 days, 18 patients received placebo, followed by aspirin 100 mg/day, and then aspirin 325 mg/day. Single blind prospective assessment of reflected wave and time reflection by radial applanation tonometry; pulse wave velocity; blood pressure; thromboxane B2 (TxB2) and prostaglandins in plasma and urine was performed. Aspirin 325 mg/day induced a significant increase in augmentation index of reflected wave (P<0.0001 and P=0.0013 vs. placebo and aspirin 100 mg, respectively) and a significant decrease in reflected wave traveling times (P=0.0007 vs. placebo). Aspirin 100 mg/day produced a similar, though non-significant, trend in these parameters compared with placebo. Both aspirin treatments produced a statistically significant decrease in serum TxB2 (P<0.0001) but did not have an effect on the metabolite of prostaglandin I2 (P=0.136). CONCLUSION: This study demonstrates the existence of a dose-mediated deleterious effect of aspirin upon arterial functional properties in CHF patients treated with ACEI.
No takes yet. Share an insight, caveat, or question.
Meune et al. (2003) studied Chronic heart failure treated with ACE inhibitors (n=18). Aspirin vs. Placebo was evaluated on Augmentation index of reflected wave (p=<0.0001). Aspirin /day increased the augmentation index of reflected wave and decreased reflected wave traveling times compared to placebo in CHF patients on ACEIs.
Synapse has enriched 10 related papers. Consider them for comparative context: