Preoperative low-dose aspirin (20 mg daily) inhibited aortic and saphenous vein prostacyclin production by 50% compared to controls, without significantly increasing surgical blood loss.
Observational
Does low-dose aspirin (20 mg daily) affect vascular prostacyclin and platelet thromboxane production in patients with atherosclerosis undergoing coronary bypass surgery?
Preoperative low-dose aspirin (20 mg daily) in CABG patients significantly inhibits both platelet thromboxane and vascular prostacyclin production without increasing surgical bleeding.
Absolute Event Rate: 51% vs 130%
The relationship between the antithrombotic and antiplatelet effects of aspirin is complex, since aspirin influences other systems that protect against thrombosis as well as inhibiting platelet function. We investigated possible cumulative effects of low-dose aspirin on vascular production of prostacyclin in patients with documented atherosclerotic cardiovascular disease. Candidates for coronary artery vein graft bypass ingested 20 mg of aspirin daily during the week before surgery, and platelet aggregation, platelet formation of thromboxane A2 (TXA2), aortic and saphenous vein production of prostacyclin (PGI2), and hemostatic status were measured at the time of the bypass surgery. Low-dose aspirin markedly inhibited platelet aggregation responses and reduced TXA2 generation by greater than 90%, effects similar to those observed with much higher doses of aspirin. Both aortic and saphenous vein production of PGI2 were inhibited by 50% compared with PGI2 produced by vascular tissues of control subjects who received no aspirin preoperatively (51 +/- 10 pg 6-keto-PGF1 alpha/mg aortic wet weight mean +/- SEM in aspirin-treated subjects vs 130 +/- 16 pg/mg in control subjects, and 71 +/- 8 pg/mg saphenous vein wet weight vs 131 +/- 17 pg/mg). Blood loss at surgery was not significantly increased by preoperative low-dose aspirin as measured by chest tube drainage (754 +/- 229 ml in aspirin-treated subjects vs 645 +/- 271 ml in control subjects), hematocrit nadir (31.2 +/- 1.9% vs 31.8 +/- 1.7%), or transfusions (2.2 +/- 1.3 units of red blood cells vs 2.2 +/- 1.7 units).(ABSTRACT TRUNCATED AT 250 WORDS)
Weksler et al. (Fri,) conducted a observational in Atherosclerotic cardiovascular disease. Low-dose aspirin vs. No aspirin preoperatively was evaluated on Aortic production of prostacyclin (PGI2) in pg/mg wet weight. Preoperative low-dose aspirin (20 mg daily) inhibited aortic and saphenous vein prostacyclin production by 50% compared to controls, without significantly increasing surgical blood loss.