Key result
Oral aspirin significantly inhibited platelet aggregation and reduced TxA2-release by ≥99.5% after 5 days in CABG patients, with no evidence of inherent or acquired aspirin resistance.
Why the study?
Does 325 mg oral aspirin compared to 100 mg oral aspirin improve platelet inhibition in patients undergoing CABG surgery?
Population
Patients undergoing coronary artery bypass graft (CABG) surgery
Comparison
Oral aspirin 325 mg for 5 days vs Oral aspirin 100 mg for 5 days
Design
Cohort
Follow-up
5 days
Authors
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Both aspirin doses inhibit platelets effectively post-CABG without resistance; hypothesis-generating for dose optimization in randomized trials.
Does 325 mg oral aspirin compared to 100 mg oral aspirin improve platelet inhibition in patients undergoing CABG surgery?
Both 100 mg and 325 mg doses of aspirin effectively inhibit platelet function after CABG surgery, with no evidence of inherent or acquired aspirin resistance.
Lim et al. (2006) studied Coronary artery bypass graft (CABG) surgery. Aspirin vs. 100 mg vs 325 mg was evaluated on Platelet function evaluated by changes in collagen-induced thromboxane-A2 (TxA2) release and platelet aggregation. Oral aspirin significantly inhibited platelet aggregation and reduced TxA2-release by ≥99.5% after 5 days in CABG patients, with no evidence of inherent or acquired aspirin resistance.
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