Why the study?
Does cardiac surgery impair the antiplatelet effect of aspirin due to platelet activation?
Population
40 patients undergoing cardiac surgery
Comparison
Oral aspirin started on day 1 after CABG; in… vs AVR patients and pre-surgery baseline values
Design
Cohort
Follow-up
10 days
Authors
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May blunt aspirin's antiplatelet effects after CABG; hypothesis-generating for resistance mechanisms and optimal regimens.
Does cardiac surgery impair the antiplatelet effect of aspirin due to platelet activation?
Cardiac surgery induces an in vitro 'resistance' of platelets to aspirin, and oral aspirin after CABG may have impaired antiplatelet effects due to increased platelet activity.
Zimmermann et al. (2007) studied this question.
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