Key result
Coronary artery bypass grafting was associated with a transient impairment in aspirin antiplatelet effect and significantly elevated soluble thrombomodulin levels (13 vs. 3 ng/ml; P=0.0011).
Population
18 patients on 100 mg/day aspirin before and after coronary artery bypass grafting (CABG)
Design
Cohort
Follow-up
1 week
Authors
Loading...
May increase early graft thrombosis risk post-CABG; hypothesis-generating for intensified perioperative antiplatelet regimens in RCTs.
Observational (n=18)
Absolute Event Rate: 13% vs 3%
p-value: p=0.0011
CABG induces a transient impairment in the antiplatelet effect of aspirin, likely due to increased platelet turnover driven by inflammation, which may increase the risk of graft thrombosis.
Arazi et al. (2010) conducted an observational in Coronary artery bypass grafting (n=18). Coronary artery bypass grafting (CABG) vs. Preoperative baseline was evaluated on Soluble thrombomodulin (sTM) levels (p=0.0011). Coronary artery bypass grafting was associated with a transient impairment in aspirin antiplatelet effect and significantly elevated soluble thrombomodulin levels (13 vs. 3 ng/ml; P=0.0011).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: