Why the study?
Does aspirin resistance after CABG involve impaired inhibition of platelet functions and COX-1?
Population
Patients undergoing coronary artery bypass grafting (CABG)
Comparison
Aspirin, celecoxib, and terbogrel vs Pre-CABG baseline (control)
Design
Cohort
Follow-up
10 days after CABG
Authors
Loading...
May warrant caution with standard aspirin after CABG; leaves open COX-1 impairment mechanisms for prospective trials.
Does aspirin resistance after CABG involve impaired inhibition of platelet functions and COX-1?
Platelet aspirin resistance after CABG involves impaired in vivo and in vitro inhibition of platelet functions, likely due to disturbed COX-1 inhibition rather than COX-2 upregulation.
Zimmermann et al. (2003) studied this question.