What question did this study set out to answer?

To evaluate the efficacy of aspirin and assess the incidence and duration of aspirin resistance in patients undergoing off-pump coronary artery bypass grafting (OPCAB).

June 1, 2011European Journal of Cardio-Thoracic SurgeryOpen Access

Aspirin resistance in off-pump coronary artery bypass grafting

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Why the study?

What is the incidence and time course of aspirin resistance in patients undergoing off-pump CABG compared to medically treated controls?

Population

331 patients, including 111 undergoing primary off-pump coronary artery bypass grafting and 220 controls…

Comparison

Aspirin administration post-OPCAB vs Aspirin administration in medically treated…

Design

Cohort

Follow-up

6 months

Authors

ZWZanxin WangChinese Academy of Medical Sciences & Peking Union Medical College FGFei GaoInterventional / Structural Cardiology JMJianlong MenTianjin Medical University General Hospital

Discussion

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Implication

May warrant early platelet monitoring or alternative regimens post-OPCAB; leaves open impact on graft patency or events.

Key Points

To evaluate the efficacy of aspirin and assess the incidence and duration of aspirin resistance in patients undergoing off-pump coronary artery bypass grafting (OPCAB).
Recruited 331 patients, comprising 111 who underwent primary OPCAB (group A) and 220 controls with ischemic heart disease managed with medical therapy.
Measured arachidonic acid-induced platelet aggregation and urinary 11-dehydro thromboxane B2 (11-dehydroTxB2) at baseline and following aspirin administration on postoperative days 1, 4, and 10.
Completed a 6-month follow-up evaluation in patients identified with postoperative aspirin resistance.
On postoperative day 1, 29.7% (33/111) of OPCAB patients were aspirin resistant, with resistance declining to 16.2% (18/111) on day 4, 4.5% (5/111) on day 10, and 0% (0/33) by 6 months.
Aspirin-resistant patients had significantly higher platelet aggregation and urinary 11-dehydroTxB2 levels at all time points than aspirin-sensitive patients, whereas 100% of controls demonstrated aspirin sensitivity.

Structured PICO

What is the incidence and time course of aspirin resistance in patients undergoing off-pump CABG compared to medically treated controls?

Population

331 patients, including 111 undergoing primary off-pump coronary artery bypass grafting (OPCAB) and 220 controls with ischaemic heart disease

Intervention

Aspirin administration post-OPCAB

Comparator

Aspirin administration in medically treated ischaemic heart disease controls

Outcome

Incidence of aspirin resistance (measured by arachidonic acid-induced platelet aggregation and urinary 11-dehydro thromboxane B2) at baseline, days 1, 4, and 10, and 6 monthssurrogate

Aspirin resistance is a transient phenomenon occurring in approximately 30% of patients early after off-pump CABG, resolving completely by 6 months.

Cite This Study

Wang et al. (2011) studied this question.

synapsesocial.com/papers/6a80aaa01024bacc9692c2ba https://doi.org/10.1016/j.ejcts.2011.04.021

Topics

Dual antiplatelet therapy

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Aspirin resistance in off-pump coronary artery bypass grafting

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Aspirin resistance in off-pump coronary artery bypass grafting

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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