July 24, 2009European Journal of Clinical Investigation
Postoperative development of aspirin resistance following coronary artery bypass
Why the study?
Does aspirin resistance develop postoperatively in patients undergoing CABG and does it affect clinical outcomes?
Population
59 patients undergoing coronary artery bypass grafting (on-pump, off-pump and combined procedures)
Comparison
Aspirin therapy with assessment of aspirin… vs Patients without aspirin resistance
Design
Cohort
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
Post-CABG aspirin resistance is common with a nonsignificant mortality trend; hypothesis-generating and should not yet change practice.
Structured PICO
Does aspirin resistance develop postoperatively in patients undergoing CABG and does it affect clinical outcomes?
P
Population
59 patients undergoing coronary artery bypass grafting (on-pump, off-pump and combined procedures)
I
Intervention
Aspirin therapy with assessment of aspirin resistance by arachidonic acid induced platelet aggregometry
C
Comparator
Patients without aspirin resistance (normal reaction to aspirin)
O
Outcome
Incidence of preoperative and postoperative aspirin resistance, and clinical outcomes at 12-month follow upsurrogate
Aspirin resistance is a common but transient phenomenon after CABG that may be associated with a trend toward worse clinical outcomes.
Cite This Study
Kempfert et al. (2009) studied this question.