Key result
Preoperative continuation of aspirin in patients undergoing off-pump coronary artery bypass graft surgery did not affect perioperative platelet activation but significantly impaired arachidonic acid-stimulated platelet aggregation.
Why the study?
Does preoperative aspirin continuation reduce perioperative platelet activation and dysfunction in patients undergoing elective OPCAB?
Population
48 adult patients scheduled for elective off-pump coronary artery bypass graft surgery, mean age 66-67…
Comparison
Aspirin 100 mg/day continued every morning until… vs Aspirin discontinued 4 days before the operative…
Design
RCT, 1:1 randomization using random sequence of size 2 blocks and concealed…
Follow-up
48 hours postoperatively (for primary endpoint)
Authors
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Supports aspirin continuation before OPCAB without excess bleeding; extends platelet data to off-pump settings.
RCT (n=48)
Double-blind
1:1 using random sequence of size 2 blocks
No
Does preoperative aspirin continuation reduce perioperative platelet activation and dysfunction in patients undergoing elective OPCAB?
Preoperative continuation of aspirin in OPCAB impairs platelet aggregation but does not significantly affect perioperative platelet activation or postoperative bleeding.
Lee et al. (2017) conducted an RCT in Off-pump coronary artery bypass graft surgery (OPCAB) (n=48). Aspirin vs. Aspirin discontinuation 4 days before surgery was evaluated on Increment of CD62P expression at 48 h postoperatively. Preoperative continuation of aspirin in patients undergoing off-pump coronary artery bypass graft surgery did not affect perioperative platelet activation but significantly impaired arachidonic acid-stimulated platelet aggregation.
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