Key result
Continuation of preoperative aspirin until the day of surgery did not significantly increase postoperative chest tube drainage (median 310 mL vs 350 mL) or transfusion requirements compared to stopping aspirin five days prior.
Why the study?
Practice for routine continuation of preoperative aspirin remains inconsistent due to concerns regarding increased postoperative bleeding, despite evidence supporting its continuation to improve coronary artery bypass outcomes.
Does continuing preoperative aspirin 75 mg until the day of surgery increase postoperative bleeding in patients undergoing off-pump coronary artery bypass grafting?
Population
74 patients undergoing OPCABG at a single center
Comparison
Aspirin 75 mg continued until surgery day vs stopped five days before surgery
Design
Prospective cohort study
Follow-up
Seventy-two hours
Authors
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May support continuing aspirin until off-pump CABG without excess bleeding; leaves open need for RCTs before practice change.
Cohort (n=74)
No
Does continuing preoperative aspirin 75 mg until the day of surgery increase postoperative bleeding in patients undergoing off-pump coronary artery bypass grafting?
Absolute Event Rate: 310% vs 350%
Continuing low-dose aspirin (75 mg) until the day of off-pump coronary artery bypass grafting does not increase postoperative bleeding or transfusion requirements compared to stopping it five days prior.
Al-Manzo et al. (2021) conducted a cohort in Coronary Artery Disease undergoing Off-Pump Coronary Artery Bypass Grafting (n=74). Preoperative continuation of aspirin vs. Aspirin stopped 5 days before surgery was evaluated on Total amount of postoperative chest tube drainage. Continuation of preoperative aspirin until the day of surgery did not significantly increase postoperative chest tube drainage (median 310 mL vs 350 mL) or transfusion requirements compared to stopping aspirin five days prior.
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