Key result
Preoperatively continued aspirin use was not associated with a significantly increased risk of the composite outcome of in-hospital death, stroke, and reoperation for bleeding (2.8% vs 1.6%, p=0.10) in patients undergoing off-pump coronary artery bypass grafting.
Why the study?
Does preoperatively continued aspirin use affect early and mid-term outcomes in patients receiving off-pump CABG?
Cohort (n=1,418)
No
Does preoperatively continued aspirin use affect early and mid-term outcomes in patients receiving off-pump CABG?
Absolute Event Rate: 2.8% vs 1.6%
p-value: p=0.10
Preoperative continuation of aspirin in off-pump CABG appears safe without increasing bleeding risks and may reduce mid-term angina recurrence.
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Preoperative aspirin continuation appears safe in off-pump CABG without excess bleeding; leaves open need for RCTs to guide practice.
Xiao et al. (2015) conducted a cohort in Coronary Artery Disease requiring off-pump CABG (n=1,418). Preoperatively continued aspirin use vs. Preoperative nonaspirin users (aspirin withdrawn for >5 days before operation) was evaluated on Composite outcome of in-hospital death, stroke and reoperation for bleeding (p=0.10). Preoperatively continued aspirin use was not associated with a significantly increased risk of the composite outcome of in-hospital death, stroke, and reoperation for bleeding (2.8% vs 1.6%, p=0.10) in patients undergoing off-pump coronary artery bypass grafting.
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