Key result
Intravenous aspirin significantly reduced platelet aggregability and laboratory aspirin resistance 1 h and 24 h after administration in patients after coronary artery bypass grafting.
Why the study?
Does intravenous aspirin reduce laboratory aspirin resistance in patients after on-pump CABG?
Population
42 patients after on-pump coronary artery bypass surgery receiving oral aspirin 100 mg once daily, and 120…
Comparison
Intravenous aspirin 300 mg. vs Baseline platelet function prior to intravenous…
Design
Cohort
Follow-up
24 hours after intravenous aspirin administration
Authors
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May support early IV aspirin post-CABG; hypothesis-generating and requires RCTs before practice change.
Does intravenous aspirin reduce laboratory aspirin resistance in patients after on-pump CABG?
Intravenous aspirin appears to be a promising approach for reducing laboratory aspirin resistance during the postoperative phase of CABG.
Bach et al. (2009) studied Coronary artery bypass grafting (CABG) (n=162). Intravenous aspirin vs. Oral aspirin (baseline) and healthy controls was evaluated on Platelet aggregability and laboratory aspirin resistance. Intravenous aspirin significantly reduced platelet aggregability and laboratory aspirin resistance 1 h and 24 h after administration in patients after coronary artery bypass grafting.
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