Why the study?
Does a single intravenous dose of aspirin rapidly inhibit platelet aggregation and thromboxane A2 production in healthy male subjects?
Population
10 healthy male subjects
Comparison
Single intravenous low dose or high dose of… vs Placebo infused over a 60 min period
Design
RCT, randomized, single-blind
Follow-up
24 hours
Authors
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Low-dose IV aspirin achieves rapid platelet inhibition with greater prostacyclin sparing than high dose; supports its preference in acute settings and extends RCT dosing data.
Does a single intravenous dose of aspirin rapidly inhibit platelet aggregation and thromboxane A2 production in healthy male subjects?
Intravenous low-dose (50 mg) aspirin rapidly inhibits platelet aggregation and thromboxane synthesis within 30 minutes while partially sparing systemic prostacyclin formation.
Böger et al. (1993) studied this question.
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