Why the study?
Does intravenous aspirin infusion inhibit platelet function in a time- and concentration-dependent manner in human volunteers?
Population
4 human volunteers
Comparison
Intravenous aspirin infusions to achieve… vs Intravenous infusion to achieve 0 mumol/l plasma…
Design
Other
Follow-up
3 hours
Authors
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May enable titratable platelet inhibition with low-dose IV aspirin in volunteers; leaves open clinical translation and optimal patient dosing.
Does intravenous aspirin infusion inhibit platelet function in a time- and concentration-dependent manner in human volunteers?
Low-dose intravenous aspirin progressively inhibits platelet function in vivo in a time- and concentration-dependent manner.
Wilson et al. (1990) studied this question.
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