Key result
Single-dose aspirin rapidly inhibits platelet activation and lowers PAI-1 for up to 4 days.
Why the study?
Does a single oral dose of aspirin inhibit platelet function and reduce plasma PAI-1 levels in healthy volunteers?
Population
34 normal healthy male and female volunteers
Design
Cohort
Follow-up
up to 4 days
Authors
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Should not change practice; hypothesis-generating for sustained platelet and PAI-1 effects in healthy volunteers.
Does a single oral dose of aspirin inhibit platelet function and reduce plasma PAI-1 levels in healthy volunteers?
A single 650 mg oral dose of aspirin rapidly inhibits arachidonic acid-induced platelet activation and reduces plasma PAI-1 for up to 4 days, but may cause a rebound response to other platelet agonists.
Mousa et al. (2008) studied Healthy volunteers (n=34). Aspirin was evaluated on Ex vivo arachidonic acid-mediated platelet functions and plasma PAI-1 levels. A single 650 mg oral dose of aspirin rapidly inhibited arachidonic acid-induced platelet activation and reduced plasma PAI-1 levels for up to 4 days in healthy volunteers.
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