Key result
Stimulation with collagen and arachidonic acid detected platelet aggregation as early as 4 hours after 650 mg aspirin ingestion, requiring only 2.5% of aspirin-free platelets.
Why the study?
Does the combination of aggregating agents detect early entry of new platelets into the circulation after aspirin ingestion in normal subjects?
Population
14 normal subjects (platelet-rich plasmas)
Follow-up
up to 72 hours
Authors
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Combined agonists detect early platelet recovery after aspirin in normals; leaves open relevance to patient dosing or monitoring.
Does the combination of aggregating agents detect early entry of new platelets into the circulation after aspirin ingestion in normal subjects?
The use of combined aggregating agents demonstrates that new, unacetylated platelets enter the circulation as early as 4 hours after aspirin ingestion.
Minno et al. (1983) studied Healthy volunteers (n=14). Aspirin was evaluated on Platelet aggregation, secretion, and thromboxane-B2 formation. Stimulation with collagen and arachidonic acid detected platelet aggregation as early as 4 hours after 650 mg aspirin ingestion, requiring only 2.5% of aspirin-free platelets.
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