Why the study?
Do different dosages of aspirin alter platelet aggregability and thromboxane/prostacyclin metabolite excretion in healthy male volunteers?
Population
15 healthy male volunteers
Comparison
Aspirin sequential dosage regimens: 37.5 mg/day… vs No treatment (baseline)
Design
Other, open-label
Follow-up
18 days
Authors
Loading...
May question once-daily aspirin adequacy for sustained inhibition; leaves open optimal dosing frequency for clinical and research evaluation.
Do different dosages of aspirin alter platelet aggregability and thromboxane/prostacyclin metabolite excretion in healthy male volunteers?
Once daily dosing of aspirin might be insufficient for sustained antiplatelet effects due to the recovery of COX-dependent platelet aggregation within 24 hours.
Perneby et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: