Why the study?
Does a single oral dose of 600 mg aspirin reduce platelet aggregation response to arachidonic acid in volunteers?
Population
6 volunteers
Comparison
Single oral dose of 600 mg aspirin vs Pre-aspirin baseline (within-subject comparison)
Design
Cohort
Follow-up
10 days
Authors
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Hypothesis-generating for aspirin's effects on platelet precursors; should not yet change clinical dosing without randomized confirmation.
Does a single oral dose of 600 mg aspirin reduce platelet aggregation response to arachidonic acid in volunteers?
A single 600 mg dose of aspirin completely inhibits arachidonic acid-induced platelet aggregation for 4 days, suggesting an effect on platelet precursors in the bone marrow in addition to circulating platelets.
Bye et al. (1979) studied this question.
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