Why the study?
Does aspirin inhibit thrombus formation in an in vivo laser-induced thrombosis model?
Population
In vivo helium-neon (He-Ne) laser-induced thrombosis model (including granulocyte-depleted animals)
Design
Preclinical
Follow-up
up to 180 minutes
Authors
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Should not change clinical practice; extends preclinical evidence for arteriolar-selective, dose-dependent aspirin effects in thrombosis models.
Does aspirin inhibit thrombus formation in an in vivo laser-induced thrombosis model?
Aspirin exerts potent, dose-dependent antithrombotic effects in arterioles in vivo, independent of leucocyte-related mechanisms, challenging the clinical relevance of the 'aspirin dilemma'.
Nagamatsu et al. (1999) studied this question.