Key result
Aspirin reduced platelet thrombus volume by 45% (p<0.03) and fibrin deposition by 70% (p<0.004) at 60% stenosis, but had no effect at 80% stenosis with higher shear rates.
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May not reduce thrombosis at high-shear stenoses; leaves open differential antiplatelet effects by hemodynamic conditions.
Effect estimate: 45% reduction
p-value: p=<0.03
Barstad et al. (1996) studied Arterial thrombus formation. Aspirin vs. Control was evaluated on Platelet thrombus volume at 60% stenosis (45% reduction, p=<0.03). Aspirin reduced platelet thrombus volume by 45% (p<0.03) and fibrin deposition by 70% (p<0.004) at 60% stenosis, but had no effect at 80% stenosis with higher shear rates.
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