Why the study?
Does intravenous aspirin pretreatment attenuate TPA-induced clot lysis in rabbit models of embolic stroke?
Does intravenous aspirin pretreatment attenuate TPA-induced clot lysis in rabbit models of embolic stroke?
Intravenous aspirin pretreatment paradoxically attenuates TPA-induced cerebrovascular thrombolysis in rabbit models of embolic stroke, likely due to loss of endothelial prostacyclin production.
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Should not alter aspirin pretreatment before tPA in stroke; leaves open translation to humans.
Thomas et al. (1995) studied this question.
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