What question did this study set out to answer?

To investigate the opposing effects of high-dose aspirin on thrombus formation and vessel wall PGI(2) activity.

October 1, 1978Journal of Clinical InvestigationOpen Access

Thrombogenic Effect of High-Dose Aspirin in Rabbits

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Why the study?

Does high-dose aspirin augment experimental thrombosis in rabbits?

Population

Rabbits with experimentally induced venous thrombi

Comparison

Aspirin 200 mg/kg vs Sodium salicylate 200 mg/kg, aspirin 10 mg/kg…

Design

Preclinical

Authors

JKJohn G. KeltonMcMaster University Medical Centre JHJ. HirshASTER CCC. J. CarterMcMaster University Medical Centre

Discussion

Member takes

Implication

High-dose aspirin effects in rabbits are hypothesis-generating; should not alter clinical dosing or practice.

Key Points

To investigate the opposing effects of high-dose aspirin on thrombus formation and vessel wall PGI(2) activity.
Studied the effects of 200 mg/kg aspirin on venous thrombus formation in rabbits.
Used the thrombin-induced [(14)C]serotonin release assay to evaluate vessel wall PGI(2)-like activity.
Compared effects with sodium salicylate and lower doses of aspirin.
200 mg/kg aspirin increased thrombus size compared to controls (P < 0.001).
200 mg/kg aspirin completely inhibited vessel wall PGI(2)-like activity.
Delay of 2.5 hours between vessel damage and aspirin administration prevented thrombogenic effects.

Structured PICO

Does high-dose aspirin augment experimental thrombosis in rabbits?

Population

Rabbits with experimentally induced venous thrombi

Intervention

Aspirin 200 mg/kg

Comparator

Sodium salicylate 200 mg/kg, aspirin 10 mg/kg, or controls

Outcome

Fibrin accretion onto experimentally induced venous thrombi (thrombus size) and PGI2-like activity of vessel wallsurrogate

High-dose aspirin augments experimental thrombosis in rabbits by inhibiting vessel wall PGI2 synthesis, highlighting a potential pro-thrombotic effect at very high doses.

Cite This Study

Kelton et al. (1978) studied this question.

synapsesocial.com/papers/6a12656ef7bd4f5c7da63d90 https://doi.org/10.1172/jci109203

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Thrombogenic Effect of High-Dose Aspirin in Rabbits

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Thrombogenic Effect of High-Dose Aspirin in Rabbits

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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