Why the study?
Does aspirin improve impaired cholinergic forearm vasodilatation in hypercholesterolemic patients?
Population
20 individuals (10 hypercholesterolemic patients and 10 matched controls), aged 38-63 years.
Comparison
Aspirin added to brachial artery infusion of… vs Brachial artery infusion of acetylcholine and…
Design
Case-control
Authors
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Implicates vasoconstrictor prostanoids in endothelial dysfunction; leaves open aspirin's therapeutic role in hypercholesterolemia.
Does aspirin improve impaired cholinergic forearm vasodilatation in hypercholesterolemic patients?
Aspirin partially reverses impaired endothelium-dependent vasodilatation in hypercholesterolemic patients, suggesting a role for vasoconstrictor prostanoids in endothelial dysfunction.
Joseph P. Noon (1998) studied this question.
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