Key result
Murine models, particularly using different genetic backgrounds and routes of infection such as the oral route, are essential for understanding the pathogenesis and immune responses of coxsackieviruses.
Why the study?
Mouse models are used to better understand the pathogenesis of coxsackieviruses to enhance the development of diagnostics, treatment, and preventive measures.
Murine models are essential for understanding the pathogenesis, tissue tropism, and immune responses of coxsackievirus infections, including their role in human diseases such as myocarditis and type 1 diabetes.
Answers are grounded in this paper and cite their sources.
Supports refined murine model selection in research; leaves open translation to human myocarditis or diabetes.
Understanding the pathogenesis of communicable diseases often involves animal models. Mouse models are studied by researchers to achieve a better understanding of the relationship between the biological, physiochemical, and antigenic properties of the infectious agent, as well as the histopathological, immunological, and functional changes in the living system and the target organs, in short, the pathophysiological processes that the communicable agents bring about. The long-term objectives of the in vivo studies are important from a medical point of view, as they represent faithful (reliable and similar) human responses, which enhance the development of diagnostics, treatment, and measures for preventing the spread of the disease. Our work is devoted to the murine models used for understanding the pathogenesis of coxsackieviruses. We describe different mouse models used for studying the diseases caused by coxsackieviruses and the immune responses in different mouse models. We then shortly elucidate experiences from our laboratory related to the oral route of infection, and compare the similarities and differences we found in this model.
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Bopegamage et al. (2020) conducted a review in Coxsackievirus infection. Murine experimental models was evaluated. Murine models, particularly using different genetic backgrounds and routes of infection such as the oral route, are essential for understanding the pathogenesis and immune responses of coxsackieviruses.
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