Towards precision disease-modelling in experimental myocarditis
Key result
Intravenous administration of the H3N-375TS variant to mice resulted in myocarditis without pancreatic viral infection, providing a more accurate model of human viral myocarditis.
Population
NMRI mice
Comparison
Intravenous administration of recombinant CVB… vs Uninfected mice and classic CVB3 model
Design
Editorial
Follow-up
Up to 28 days
Authors
Discussion
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Implication
A novel cardiac-selective CVB3 mouse model successfully recapitulates human viral myocarditis without the confounding biological noise of pancreatitis.
Structured PICO
P
Population
NMRI mice
I
Intervention
Intravenous administration of recombinant CVB variant H3N-375TS
C
Comparator
Uninfected mice and classic CVB3 model
O
Outcome
Development of myocarditis without pancreatic viral infection or tissue damagesurrogate
Limitations
- Experimental modelling cannot replace clinical studies, which allow genomic and molecular assessment and patient stratification based on phenotypic description and co-morbidities.
- Experimental models cannot reproduce the complex genetic and environmental factors or comorbidities present in human inflammatory cardiomyopathies.
Cite This Study
Protonotarios et al. (2020) conducted an editorial in Myocarditis. H3N-375TS variant vs. classic coxsackievirus B3 model was evaluated. Intravenous administration of the H3N-375TS variant to mice resulted in myocarditis without pancreatic viral infection, providing a more accurate model of human viral myocarditis.