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This research aims to understand the role of semaphorin 4D in platelet responses during vascular injury.

Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury

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This research aims to understand the role of semaphorin 4D in platelet responses during vascular injury.
Platelets were analyzed for sema4D and receptor expression during activation.
In vivo arterial occlusion was assessed in mice lacking sema4D.
Platelet responses were measured in vitro for collagen interaction.
Mice lacking sema4D showed delayed arterial occlusion after vascular injury (p<0.05).
Platelet activation increased sema4D and CD72 surface expression, followed by shedding of sema4D.
Inhibition of metalloprotease ADAM17 blocked the shedding of sema4D.

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Randomized trial shows semaphorin 4D enhances thrombus formation in platelets, suggesting its dual role in vascular injury responses.

Zhu et al. (2007) studied this question.

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