Why the study?
Does activated protein C prevent lipopolysaccharide-induced pulmonary vascular injury in rats?
Does activated protein C prevent lipopolysaccharide-induced pulmonary vascular injury in rats?
Activated protein C attenuates endotoxin-induced pulmonary vascular injury in rats via a mechanism independent of its anticoagulant activity, likely through inhibition of leukocyte accumulation.
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Indicates APC attenuates rat pulmonary injury independently of anticoagulation; leaves open applicability to human sepsis-induced ARDS.
Murakami et al. (1996) studied this question.
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