Key result
Acute immune thrombocytopenia in mice increased thrombopoietin levels to more than twice the value of control mice, reaching a maximum 12 hours after induction.
Thrombopoietin levels peak at more than twice control values 12 hours after immune-induced thrombocytopenia in mice.
Caution against extrapolating murine TPO kinetics to patients; leaves open human validation studies.
Thrombopoietin levels in thrombocytopenic mice assayed by 75Se-se-lenomethionine incorporation into blood platelets reached a maximum 12 h after the induction of an acute, immune thrombocytopenia; that was more than twice the value in control mice. The implications of this finding are discussed with reference to the kinetics of megakaryocyte production.
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Nakeff et al. (2009) studied this question. Acute immune thrombocytopenia in mice increased thrombopoietin levels to more than twice the value of control mice, reaching a maximum 12 hours after induction.
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