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May 1, 1999British Journal of HaematologyOpen Access

The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat

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Population

Rats with non-immune thrombocytopenia induced by busulphan

Comparison

Busulphan administration to induce… vs Animals with a normal platelet count

Design

Preclinical

Follow-up

Up to 20 days (14 days post-busulphan plus up to 6 days)

Authors

CYChun YangBeihua UniversityYLYan Chun LiCross-Cutting CardiologyDKDavid J. KuterBoston Medical Center

Discussion

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Implication

Supports platelet-mass clearance as TPO regulator in animals; leaves open human validation and clinical translation.

Structured PICO

P
Population
Rats with non-immune thrombocytopenia induced by busulphan
I
Intervention
Busulphan administration to induce thrombocytopenia, followed by platelet transfusion
C
Comparator
Animals with a normal platelet count
O
Outcome
Circulating thrombopoietin (TPO) levelssurrogate

Circulating TPO levels are regulated by the ability of the platelet mass to bind and remove TPO from the circulation, rather than by changes in TPO transcription or translation.

Cite This Study

Yang et al. (1999) studied this question.

synapsesocial.com/papers/6a958cd67ee17f80122cc1b6https://doi.org/10.1046/j.1365-2141.1999.01359.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Murine thrombopoietin mRNA levels are modulated by platelet count1995 · 200 citations
  2. 2The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit1995 · 397 citations
  3. 3The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production.1994 · 451 citations
  4. 4Both subunits of rat liver ferritin are regulated at a translational level by iron induction1986 · 172 citations
  5. 5Analysis of megakaryocyte ploidy in rat bone marrow cultures1989 · 33 citations