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July 1, 1995The Journal of Biochemistry

Purification and Characterization of Thrombopoietin1

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Population

Sublethally irradiated rats (n=1,100), rat megakaryocyte progenitor cells (CFU-MK), COS-1 cells, and mice

Design

Preclinical

Authors

TKTakashi KatoVascular MedicineKOKinya OgamiKirin (Japan)YSYoshihiro ShimadaSetsunan University

Discussion

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Implication

Establishes TPO as c-Mpl ligand in rodent models; leaves open therapeutic translation to human thrombopoiesis.

Structured PICO

P
Population
Sublethally irradiated rats (n=1,100), rat megakaryocyte progenitor cells (CFU-MK), COS-1 cells, and mice
I
Intervention
Purification of thrombopoietin (TPO) from rat plasma, cloning of rat and human TPO cDNAs, and expression of TPOs
O
Outcome
Production of megakaryocytes and stimulation of platelet productionsurrogate

The study successfully purified thrombopoietin from irradiated rat plasma, cloned its cDNA, and demonstrated its identity as the c-Mpl ligand capable of stimulating platelet production.

Cite This Study

Kato et al. (1995) studied this question.

synapsesocial.com/papers/6a71efab75498292b70b3b91https://doi.org/10.1093/oxfordjournals.jbchem.a124883
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protein Characteristics of Thrombopoietin1996 · 6 citations
  2. 2The physiological response of thrombopoietin (c-Mpl ligand) to thrombocytopenia in the rat1999 · 4 citations
  3. 3The physiological response of thrombopoietin (c‐Mpl ligand) to thrombocytopenia in the rat1999 · 58 citations
  4. 4Thrombopoietin: From Theory to Reality1999 · 8 citations
  5. 5Thrombopoietin1999 · 15 citations